A 60 year old woman with a 10 year history of Type II diabetes presents with multiple complications including retinopathy, peripheral neuropathy and declining renal function. She has not had the urge to eat as of recently she feels “full” after a few bites. The incidence of nausea and feeling bloated occurs at least twice a day and even after a glass of water she feels bloated. She also complains of fatigue and not been able to keep up with daily chores.


Type II diabetes is a chronic condition characterized by high levels of blood glucose. It is a major global health issue and is associated with multiple complications that can significantly impact a person’s quality of life. This case study explores the clinical presentation of a 60-year-old woman with a history of Type II diabetes and manifesting several complications, including retinopathy, peripheral neuropathy, and declining renal function. Additionally, the patient experiences symptoms such as early satiety, nausea, bloating, fatigue, and reduced physical function. This assignment aims to analyze these symptoms in the context of diabetes complications and explore potential underlying mechanisms.


Type II diabetes is known to cause a variety of complications, affecting different systems in the body. In this case, the patient presents with two common complications of diabetes: retinopathy and peripheral neuropathy. Retinopathy refers to damage to the blood vessels in the retina, leading to visual impairment or even blindness. Peripheral neuropathy, on the other hand, involves damage to the nerves that carry signals between the brain and spinal cord to the rest of the body, leading to symptoms such as numbness, tingling, or pain in the extremities.

It is important to note that retinopathy and peripheral neuropathy can be caused by chronic high blood glucose levels. In diabetes, prolonged exposure to elevated glucose levels damages the small blood vessels and nerves throughout the body. The mechanisms underlying these complications are complex and multifactorial, involving processes such as oxidative stress, advanced glycation end products (AGEs) formation, and activation of inflammatory pathways. These processes ultimately lead to structural and functional abnormalities in the affected tissues.

In addition to retinopathy and peripheral neuropathy, the patient also presents with declining renal function. Diabetes is a leading cause of chronic kidney disease (CKD) worldwide. Similar to retinopathy and peripheral neuropathy, the pathogenesis of diabetic nephropathy involves multiple factors, including hemodynamic changes, oxidative stress, inflammation, and activation of renin-angiotensin-aldosterone system (RAAS). Over time, these pathological processes result in the progressive loss of kidney function, characterized by decreased glomerular filtration rate (GFR) and the presence of proteinuria.

The symptoms of early satiety, nausea, and bloating reported by the patient could be attributed to a condition known as diabetic gastroparesis. Gastroparesis is a disorder characterized by delayed emptying of the stomach contents into the small intestine. It occurs due to autonomic neuropathy, a complication of diabetes that affects the nerves controlling the gastrointestinal system. When the nerves that regulate stomach contractions are damaged, the stomach cannot empty properly, leading to symptoms such as early satiety, bloating, abdominal discomfort, and nausea.

The feeling of fullness after eating only a few bites is known as early satiety, which is a common symptom of gastroparesis. The delayed stomach emptying in gastroparesis causes food to remain in the stomach longer than usual, leading to a sensation of fullness even with small amounts of food. This can result in reduced appetite and weight loss, as experienced by the patient in this case.

Nausea and bloating are also commonly associated with gastroparesis. The delayed gastric emptying can cause food to ferment, leading to the production of gases and subsequent bloating. Additionally, the accumulation of undigested food in the stomach can cause irritation and discomfort, resulting in nausea.

The associated fatigue and reduced physical function reported by the patient could be attributed to a combination of factors. Diabetes-related complications such as retinopathy, neuropathy, and nephropathy can contribute to reduced physical abilities and fatigue. Peripheral neuropathy can cause muscle weakness, loss of sensation, and impaired balance, leading to difficulties in performing daily tasks. Nephropathy can also result in anemia, which can further contribute to fatigue.


In conclusion, this case study highlights the complex and interconnected nature of diabetes complications. The patient presented with retinopathy, peripheral neuropathy, declining renal function, early satiety, nausea, bloating, fatigue, and reduced physical function. These symptoms can be attributed to the pathophysiology of diabetes-related complications, including oxidative stress, inflammation, and nerve damage. Understanding the underlying mechanisms can aid in the management and prevention of these complications, ultimately improving the quality of life for individuals with Type II diabetes.